Anti-cancer PF299804 Dacomitinib cas 1110813-31-4

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Product Code : 1110813-31-4

Brand Name : DM

Price And Quantity

Minimum Order Quantity
1 Gram
Price Range
1.00 - 5.00 USD ($)/Gram

Product Specifications

Boiling point
665.7±55.0 °C(Predicted)
Molecular Formula
C24H25ClFN5O2

Storage
Room Temperature
Smell
No Smell

Molecular Weight
469.9390032 Pound (lb)
Shelf Life
2 Years

Taste
Odorless
Structural Formula
C24H25ClFN5O2

Medicine Name
Dacomitinib (PF299804)
Chemical Name
(E)-N-(4-((3-chloro-4-fluorophenyl)aMino)-7-Methoxyquizolin-6-yl)-4-(piperidin-1-yl)but-2-eMide

CAS No
1110813-31-4
Type
Pharmaceutical Intermediates

Grade
Medicine Grade
Usage
human pharma

Purity(%)
99
Appearance
white powder

Physical Form
Powder

Product Description

Dacomitinib is a selective and irreversible inhibitor of EGFR. It is a drug candidate for the treatment of non-small cell lung carcinoma. It is current under the Phase III clinical trials. It also shows potential for the treatment of HER-2 amplified breast cancer cells lines that are resistant to trastuzumab and lapatinib.

Dacomitinib is taken orally once-daily. It is an irreversible inhibitor of HER-1 (EGFR), HER-2 and HER-4 tyrosine kinases. Dacomitinib targets multiple receptors of the HER pathway, whereas currently marketed HER-1 (EGFR) inhibitors for non-small cell lung cancer (NSCLC) target only one receptor in this pathway,developed .

Product Name	Dacomitinib
Synonyms	PF-299804 (Dacomitinib,PF-00299804);PF299804, PF299);Dacomitinib;PF-00299804-03;PF-00299804;DacoMitinib (PF-00299804);DacoMitinib,PF299804;DacoMitinib (PF299804,PF-00299804)
CAS	1110813-31-4
MF	C24H25ClFN5O2
MW	469.9390032
EINECS	N/A
Product Categories	-;Anti-cancer&immunity;Inhibitors
Mol File	1110813-31-4.mol