Back to top
  • Send Inquiry

API VX 770 CAS 873054-44-5 Ivacaftor

API VX 770 CAS 873054-44-5 Ivacaftor
API VX 770 CAS 873054-44-5 Ivacaftor
Send Inquiry
Product Code : 873054-44-5
Brand Name : DM
Price And Quantity
  • Minimum Order Quantity
  • 1 ,
  • Price Range
  • 1.00 - 5.00 USD ($)/Gram
Product Description

Product Name:IvacaftorCAS:873054-44-5MF:C24H28N2O3MW:392.49072Mol File:873054-44-5.mol

Boiling point:550.450.0 C(Predicted)Density 1.187


the treatment of cystic fibrosis (CF) in patients who have the G551D mutation of the CF transmembrane regulator (CFTR) and are at least 6 years old. Ivacaftor (also known as VX-770) is a CFTR potentiator that increases the open probability of CFTR, thus increasing chloride secretion particularly in the 5% of CF patients with the G551D/F508 gating/ processing mutation. Ivacaftor was discovered by medicinal chemistry optimization of a lead scaffold identified through high-throughput screening of a 228,000 compound collection. In cultured bronchial epithelial cells from a CF patient with F508del, ivacaftor increased chloride secretion (EC50=81 nM). Preparation of ivacaftor is accomplished via a multistep synthesis oftwointermediates, 4-oxo-1,4-dihydroquinoline-3-carboxylic acid and 5-amino-di-tert-butylphenyl methyl carbonate, which are coupled using propane phosphonic acid anhydride (T3P) to afford the amide; deprotection of the phenol then provides ivacaftor.UsesIvacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectivelyUsesIvacaftor is used in the treatment of cystic fibrosis.


SHIJIAZHUANG DINGMIN PHARMACEUTICAL SCIENCES CO., LTD.
X


SHIJIAZHUANG DINGMIN PHARMACEUTICAL SCIENCES CO., LTD.
B No.52 Zhaiying South street,Yuhua Dostrict, Shijiazhuang, China, Shijiazhuang - 050000, Hebei, China
Ms. Lily (General Manager)

  • Send Inquiry