Classification: Antineoplastic,antimetabolite Action/Kinetics:An oral prodrug of 5'-deoxy-5-fluorouridine (5'DFUR) that is converted to5-fluorouracil (5-FU). 5-FU is metabolized to 5-fluoro-2-deoxyuridinemonophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) which cause cellinjury in two ways. First, FdUMP and the folate cofactor,N5-10-methylenetetrahydrofolate, bind to thymidylate synthase to form acovalently bound ternary complex which inhibits the formation of thymidylatefrom uracil. Thymidylate is essential for the synthesis of DNA so a deficiencyinhibits cell division. Secondly, nuclear transcriptional enzymes canmistakenly incorporate FUTP in place of uridine triphosphate during RNAsynthesis; this interferes with RNA processing and protein synthesis. Readilyabsorbed from the GI tract. Peak blood levels, capecitabine: 1.5 hr; peak bloodlevels, 5-FU: 2 hr. Food reduces the rate and extent of absorption. t1/2,capecitabine and 5-FU: 45 min. Metabolites excreted in the urine.

Application  

 1. Natural d alpha tocopherol, TocopherolPowder Applied in the Cosmetics industry, mixed tocopherol can prevent thepremature aging of skin and improve the skin's elasticity.
2. Naturald alpha tocopherol, Tocopherol Powder Applied in the Medical industry, mixedtocopherol can be used in curing pericoronitis, fatty liver, andarteriosclerosis, habitual abortion and barrenness.
3. Naturald alpha tocopherol, Tocopherol Powder Applied in the Food industry, mixedtocopherol is mainly used as an antioxidant and a fortifying agent of fattyfoods,and nutritional reinforcing agent of health care product.
4. Naturald alpha tocopherol, Tocopherol Powder Applied in feed additive for livestock,mixed tocopherol is mainly used as an antioxidant it can improve thereproductive functions of animals and increase reproductive capacity.

Specification