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Home » Products » Anti Cancer Intermediate » Fulvestrantly Powder Anti Estrogen API CAS 129453-61-8

Fulvestrantly Powder Anti Estrogen API CAS 129453-61-8

Fulvestrantly Powder Anti Estrogen API CAS 129453-61-8
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Product Code : 129453-61-8
Brand Name : DM
Price And Quantity
  • Minimum Order Quantity
  • 1g
  • Unit of Measure
  • Gram/Grams
  • Price Range
  • 10.00 - 50.00 USD ($)
Product Specifications
  • Molecular Weight
  • 606.77
  • Storage
  • Freezer
  • Taste
  • Odorless
  • Shelf Life
  • 2 Years
  • Molecular Formula
  • C32H47F5O3S
  • Melting Point
  • 104-106°C
  • Solubility
  • DMSO: >5mg/mL
  • EINECS No
  • 642-998-6
  • HS Code
  • 2937230000
  • Smell
  • No Smell
  • Structural Formula
  • C32H47F5O3S
  • Medicine Name
  • Fulvestrant
  • Chemical Name
  • 7A,17B-[9[(4,4,5,5,5-PENTAFLUOROPENTYL)SULFINYL]NONYL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL (7alpha,17beta)-nonyl)
  • CAS No
  • 129453-61-8
  • Type
  • Pharmaceutical Intermediates
  • Grade
  • Medicine Grade
  • Usage
  • Treatment of Breast Cancer
  • Purity(%)
  • 98
  • Appearance
  • white powder
  • Physical Form
  • Powder
Product Description

MW: 606.77

mp104-106°C

storagetemp. 2-8°C

ChemicalProperties White Powder

UsageA novel steroidal estrogen antagonist reported to lack any partial agonistactivity. Antineoplastic (hormonal).

 

Usage Antiestrogen

BiologicalActivity A high affinity estrogen receptor antagonist (IC 50 = 0.29nM), devoid of any partial agonism both in vitro and in vivo . Also highaffinity agonist at the membrane estrogen receptor GPR30.

ProductCategories: Intermediates & Fine Chemicals;Pharmaceuticals;NuclearReceptors;Chiral Reagents;Steroids;Sulfur & SeleniumCompounds;FASLODEX;Anti-cancer&immunity

Synonyms:ICI182,780;;-13C1-D2;FASLODEX;(7a,17b)-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol;7A,17B-[9[(4,4,5,5,5-PENTAFLUOROPENTYL)SULFINYL]NONYL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL;(7alpha,17beta)-nonyl);estra-1,3,5(10)-triene-3,17-diol,7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)

 Description:
 
Fulvestrant Acetate (trade name Faslodex, by AstraZeneca) is a drug treatment of hormone receptor-positive metastatic breastcancer in postmenopausal women with disease progression following anti-estrogentherapy. It is a completeestrogen receptor antagonist with no agonisteffects, which in addition, accelerates the proteasomal degradation of theestrogen receptor. The drug has poor oral bioavailability, and is administeredmonthly via intramuscular injection.

Applications:
 Fulvestrant Acetate is a selective estrogen receptor degrader (SERD).It is indicated for the treatment of hormone receptor positivemetastatic  breast cancer in postmenopausal women with diseaseprogression following anti-estrogen therapy. Fulvestrant Acetate provides effective second-line therapy in metastaticor locally advanced breast cancer for postmenopausal women who relapse orprogress after previous endocrine therapy. Four clinical trials in this setting showed similar efficacy to the otherhormonal agents (aromatase inhibitors and tamoxifen) with good tolerabilityprofile. Fulvestrant had a lower incidence of joint disorders. A Phase 2 clinical trial, sponsored by Atossa Genetics, is beingconducted by Dr. Sheldon Feldman, President of the The American Society ofBreast Surgeons, at Columbia University Breast Center in New York City on theuse of  Fulvestrant Acetate administered through the microcatheterinto the lactiferous duct as neoadjuvant treatment forductal carcinoma in situand invasive breast cancer.

Trade Information
  • FOB Port
  • any port in China
  • Payment Terms
  • Paypal, Letter of Credit at Sight (Sight L/C), Days after Acceptance (DA), Cash in Advance (CID), Cash Against Delivery (CAD)
  • Supply Ability
  • 100kgs Per Month
  • Delivery Time
  • 1 Week
  • Sample Policy
  • Within a certain price range free samples are available
  • Packaging Details
  • as pe request
  • Main Export Market(s)
  • Africa, Western Europe, South America, North America, Central America, Asia
  • Main Domestic Market
  • All India
  • Certifications
  • ISO9001

SHIJIAZHUANG DINGMIN PHARMACEUTICAL SCIENCES CO., LTD.
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SHIJIAZHUANG DINGMIN PHARMACEUTICAL SCIENCES CO., LTD.
B No.52 Zhaiying South street,Yuhua Dostrict, Shijiazhuang, China, Shijiazhuang - 050000, Hebei, China
Ms. Lily (General Manager)
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