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Ibrutinib/PCI-32765 Cas 936563-96-1

Ibrutinib/PCI-32765 Cas 936563-96-1
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Product Code : 936563-96-1
Brand Name : DM
Price And Quantity
  • Minimum Order Quantity
  • 1g Gram
  • Price Range
  • 10.00 - 20.00 USD ($)
Product Specifications
  • Structural Formula
  • C25H24N6O2
  • Molecular Formula
  • C25H24N6O2
  • Heavy Metal (%)
  • NMT 20ppm
  • Storage
  • Room Temperature
  • Shelf Life
  • 2 Years
  • Smell
  • No Smell
  • Molecular Weight
  • 440.5
  • Taste
  • Odorless
  • EINECS No
  • 805-642-2
  • HS Code
  • 29339900
  • Loss on Drying
  • NMT 0.5%
  • Medicine Name
  • Ibrutinib/PCI-32765
  • Chemical Name
  • (R)-1-(3-(4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidin-1-yl)prop-2-en-1-one 1-[(3R)-3-[4-AMino-3-(4-phenoxyphenyl)pyrazolo[3, 4-d]pyriMidin-1-yl]piperidin-1-yl]prop-2-en-1-one Ibrutinib (PCI-32765) 1-{3-[4-AMino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyriMidin-1-yl]-piperidin-1-yl}-propenone 1-{3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-but-3-en-1-one Factory supply high quality Ibrutinib Cas 936563-96-1 with best price and fast delivery N6-(2-Carboxyethyl) 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one Ibrutinib (PCI32765) PCI-32765 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one Ibrutinib, >=98% Lbrutinib According to Lu imatinib 2-Propen-1-one, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]- (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo-[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2- PCI-32765 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one PCI-32765 (Ibrutinib)
  • CAS No
  • 936563-96-1
  • Type
  • Pharmaceutical Intermediates
  • Grade
  • Medicine Grade
  • Usage
  • pharmaceutical Intermediates
  • Purity(%)
  • 99
  • Appearance
  • white powder
  • Physical Form
  • Powder
Product Description

Ibrutinib is ahighly selective Bruton’s tyrosine kinase (Btk) irreversibleinhibitor.PCI-32765 (Ibrutinib) is a selective and irreversiblepyrrolopyrimidine-based inhibitor of BTK with IC50 of 0.5 nM. [1] PCI-32765binds irreversibly to Cys-481 in BTK and thus is only active with other kinaseswith such a modifiable cysteine residue. In DOHH2 cells, in which the BCRpathway can be activated by anti-IgG, PCI-32765 inhibits autophosphorylation ofBTK (IC50, 11 nM), BTK's physiological substrate, PLCg (IC50, 29 nm), anddownstream ERK (IC50, 13 nm). 

PCI-32765(Ibrutinib) is a high potent irreversible BTK inhibitor with an IC50 of 0.46 nMfor the purified Btk.PCI-32765 (Ibrutinib) is highly active and well toleratedin CLL/SLL pts irrespective of high risk genomic abnormalities. Althoughfollow-up is short, the high response rate and very low progression ratesuggests that PCI-32765 (Ibrutinib) may be an important new targeted treatmentapproach for CLL pts. In ex vivo assays with whole bold, PCI-32765 (Ibrutinib)prevents the activation of human BCR with an IC50 of about 0.2 μM, while notinfluencing the activation of T cell. Treatment of CD40 or BCR activated CLLcells with PCI-32765 (Ibrutinib) results in inhibition of BTK tyrosinephosphorylation and also effectively abrogates downstream survival pathwaysactivated by this kinase including ERK1/2, PI3K, and NF-κB. In addition, PCI-32765(Ibrutinib) prevents activation-induced proliferation of CLL cells in vitro,and effectively inhibits survival signals provided externally to CLL cells fromthe microenvironment including soluble factors (CD40L, BAFF, IL-6, IL-4, andTNF-α), fibronectin engagement, and stromal cell contact. PCI-32765 isoriginally developed by Pharmacyclics. And participants is been invited for thephase I clinical trials.

 

Specification                                          

 

Items

Specifications

Results

Appearance

White to whitish crystal powder

Conforms

Loss on drying

NMT 0.5%

0.33%

Residue on ignition

NMT 0.1%

Conforms

Heavy metal

NMT 20ppm

Conforms

Assay (HPLC)

NLT 99.5%

99.77%

Related substances

NMT 0.5%

0.23%

Single impurity

NMT 0.1%

0.07%

Conclusion: Complies to the Enterprise standard  

Trade Information
  • FOB Port
  • any port in China
  • Payment Terms
  • Paypal, Letter of Credit at Sight (Sight L/C), Days after Acceptance (DA), Cash in Advance (CID), Cash Against Delivery (CAD)
  • Supply Ability
  • 100kgs Per Month
  • Delivery Time
  • 1 Week
  • Sample Policy
  • Within a certain price range free samples are available
  • Packaging Details
  • as per request
  • Main Export Market(s)
  • Africa, Western Europe, South America, North America, Central America, Asia
  • Main Domestic Market
  • All India
  • Certifications
  • ISO9001

SHIJIAZHUANG DINGMIN PHARMACEUTICAL SCIENCES CO., LTD.
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SHIJIAZHUANG DINGMIN PHARMACEUTICAL SCIENCES CO., LTD.
B No.52 Zhaiying South street,Yuhua Dostrict, Shijiazhuang, China, Shijiazhuang - 050000, Hebei, China
Ms. Lily (General Manager)
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