Isavuconazole ( R R H
Isavuconazoleworks by inhibiting lanosterol 14 alpha-demethylase, the enzymeresponsible for converting lanosterol to ergosterol by demethylation.The resulting depletion of ergosterol and build up of lanosterol compromise thestructure of the fungal cell membrane. Mammalian cells are resistant todemethylation inhibition by azoles, making the drug effects specific tofungi.
CAS No.: 241479-67-4