Specification
Item Name | Ivacaftor |
CAS NO | 873054-44-5 |
Apparence | White Powder |
Package | Aluminum Bag;Drums;Paper Box Outside |
Shipment | FedEx;DHL;UPS;TNT;EMS;Sea;Air. |
Payment | Western Union;T/T;Trade Assurance;L/C |
Warranty | 2 Years |
Certification of Analysis
Item | Specification |
Specific rotation | +39.5 to +41.5 |
State of solution(transmittance) | Clear 98.0% min. |
Chloride[cl] | 0.020% max. |
Ammonium [NH4] | 0.02% max. |
Sulfate[SO4] | 0.020% max |
Iron[Fe] | 10ppm max. |
Heavy metals [Pb] | 10ppm max |
Arsenic[As2O3] | 1ppm max |
Other amino acids | Chromatographically not detectable |
Loss on drying | 0.20% max. |
Residue on ignition[sulfated] | 0.10% max. |
Assay | 99.0% min |
Function & Application
Ivacaftor is a new therapeutic agent that actsat the cystic fibrosis transmembrane conductance regulator (CFTR) channel toalter activity. It is approved for use in patients 6 years and older withcystic fibrosis who have at least 1 G551D mutation in the CFTR gene. It isunlike any other current pharmacologic agent for cystic fibrosis in that itspecifically targets the gene defect associated with cystic fibrosis as opposedto treating resulting symptomology. Mucoactive agents, antibiotics, inhaledbeta agonists, and other anti-inflammatory agents are currently the mainstay ofcystic fibrosis treatment but can be associated with several side effects inaddition to cumbersome frequency of administration. Ivacaftor's oral dosingregimen offers a more convenient treatment option.
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