Ivermectin for a variety of most of the life cycle of nematodes (but not all nematodes) role; For dish tailfilarial microfilariae effectively, but for adult worms; For only in intestinal fecal round worms are also effective.
1. Ivermectin is thederivatives of abamectin. Ivermectin belongs to oral semisyntheticbroad-spectrum drug resistant parasites.
Inveterinary medicine ivermectin is used against many intestinal worms (but nottapeworms), most mites, and some lice. Despite this, it is not effective foreliminating ticks, flies, flukes, or fleas. It is effective against larvalheartworms, but not against adult heartworms, though it may shorten theirlives. The dose of the medicine must be very accurately measured as it is verytoxic in over-dosage.
It is sometimesadministered in combination with other medications to treat a broad spectrum ofanimal parasites. Some dog breeds (especially the Rough Collie, the SmoothCollie, the Shetland Sheepdog, and the Australian Shepherd), though, have ahigh incidence of a certain mutation within the MDR1 gene (coding forP-glycoprotein); affected animals are particularly sensitive to the toxiceffects of ivermectin.
Clinicalevidence suggests kittens are susceptible to ivermectin toxicity. A 0.01%ivermectin topical preparation for treating ear mites in cats (Acarexx) isavailable.
Ivermectinis sometimes used as an acaricide in reptiles, both by injection and as adiluted spray. While this works well in some cases, care must be taken, asseveral species of reptiles are very sensitive to ivermectin. Use in turtles isparticularly contraindicated.