Prucalopride induced contraction in a concentration dependentmanner, with a pEC50 of 7.5. Prucalopride (1, mM) significantly increased therebound contraction after electrical stimulation of the proximal colon ofguinea pigs. Prucalopride induced the relaxation of the mucosal base of theesophagus in rats, whose pEC50 was 7.8, yielding a single phase concentrationresponse curve. Prucalopride (0.1 M) concentration dependently increased theamplitude of non essential base energy contraction and acetylcholine releaseinduced by electric field stimulation in the porcine gastric ring muscle, whichcould be induced and strengthened by IBMX (10 M). Prucalopride (1 M) couldsignificantly increase the electrically induced cholinergic contraction ofporcine descending colon, and the facilitation could be significantly enhancedby Rolipram.
By stimulating the high amplitude cluster contraction of theproximal colon and inhibiting the terminal colonic contractile activity offasted dogs, Prucalopride dependently altered colonic contractile patterns.Prucalopride also caused a dose-dependent decrease in the first giant migrationcontraction (GMC) time; higher doses of prucalopride, the first GMC usuallyoccurred within the first half an hour after treatment.